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KMID : 0381920110410040235
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Korean Journal of Microscopy
2011 Volume.41 No. 4 p.235 ~ p.248
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Alterations of Calcium-binding Protein Immunoreactivities in the Hippocampus Following Traumatic Brain Injury
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Oh Yun-Jung
Kim Baek-Seon
Park Dae-Kyun
Park Kyung-Ho
Ko Jeong-Sik
Kim Duk-Soo
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Abstract
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Traumatic brain injury (TBI) is one of the leading causes of death and disability in children and adults and is a major risk factor for the development of posttraumatic epilepsy (PTE). Recent studies have provided significant insight into the pathophysiological mechanisms underlying the development of epilepsy. Although the link between brain trauma and epilepsy is well recognized, the complex biological mechanisms that result in PTE following TBI have not been fully elucidated. Therefore, this study investigated in order to identify whether or not the abnormal expression of calcium-binding proteins in the lesioned hippocampus plays a role in neuronal damage by brain trauma and whether or not the expressions may change in the contralateral hippocampus during the adaptive stage as early time point following TBI. During early time point following TBI, both parvalbumin (PV) and calbindin D-28k (CB) immunoreactivities were decreased with in the lesioned hippocampus. However, these expressions were recovered to control levels as depend on time courses. On the other hand, PV immunoreactivity in contralateral hippocampus was transiently reduced as compared to the control levels, whereas CB expression was unchanged. These findings indicate that the alterations of the calcium-binding proteins, especially PV and CB, may contribute to the neuronal death and/or damage induced by abnormal inhibitory neurotransmission at early time period following brain trauma and the development of epileptogenesis in patients with traumatic brain injury.
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KEYWORD
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Calbindin D-28K, Epileptogenesis, Parvalbumin, Posttraumatic epilepsy, TBI
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