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KMID : 0381920110410040249
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Korean Journal of Microscopy
2011 Volume.41 No. 4 p.249 ~ p.255
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Evidence for the Drp1-dependent Mitochondrial Fission in the Axon of the Rat Cerebral Cortex Neurons
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Cho Bong-Ki
Lee Seung-Bok
Sun Woong
Kim Young-Hwa
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Abstract
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Neurons utilize a large quantity of energy for their survival and function, and thereby require active mitochondrial function. Mitochondrial morphology shows dynamic changes, depending on the cellular condition, and mitochondrial dynamics are required for neuronal development and function. In this study, we found that the length of mitochondria in the distal axon is significantly shorter than that of mitochondria in dendrites or proximal axons of cerebral cortical neurons, and the reason for this difference is the local fission within the axon. We also found that suppression of Drp1, a key regulator of mitochondrial fission, resulted in significant elongation of mitochondria in axons. Collectively, these results suggest that local mitochondrial fission within the axon contributes to region-dependent mitochondrial length differences in the axons of cortical neurons.
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KEYWORD
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Axons, Cortical neurons, Drp1, Fission, Mitochondria
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