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KMID : 0381920130430020054
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Korean Journal of Microscopy
2013 Volume.43 No. 2 p.54 ~ p.64
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The Effect of Rutin on Antioxidant and Anti-inflammation in The Effect of Rutin on Antioxidant and Anti-inflammation in Streptozotocin-induced Diabetic Rats
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Lee Yoon-Jeong
Jeune Kyung-Hee
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Abstract
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The study examined the antioxidant activities and anti-inflammatory effects of rutin from the streptozotocin (STZ)-induced diabetic rats. Results revealed that the levels of plasma glucose and serum glucose were remarkably higher in the STZ-treated group compared to other groups and were significantly reduced in the STZ+rutin treated group compared to the STZ-treated group. In terms of weight, it significantly increased in all experimental groups during the experiment period except for STZ-induced diabetic group. The weight of the STZ-treated group was remarkably reduced compared to other groups. Regarding the weight of each body organ, the STZ-treated group showed higher organ weight compared to the other groups while STZ+rutin-treated group showed significantly reduced kidney and liver weights compared to those of STZ-treated group. In the pancreas tissue of the STZ-treated group, β-cell destruction and vacuolization were observed. Inflammation in the heart, liver, kidney, and retina tissues were also vividly recorded. In the STZ+rutin administered group, the heart and retina tissues were shown to be preserved normally while the liver and kidney tissues showed reduced histopathology in general compared to the STZ-treated group. Conclusionally, the rutin has the effect on the antioxidant activities and anti-inflammation in the STZ-induced diabetic rats.
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KEYWORD
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Rutin, Diabetic rats, Streptozocin, Antioxidant, Anti-inflammation
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