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KMID : 0382320050250020076
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Environmental Mutagens and Carcinogens
2005 Volume.25 No. 2 p.76 ~ p.81
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Combined Effect of Radiation and 25-Hydroxycholesterol on Human Cervix and Lung Cancer Cells in vitro
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Chae SW
Kang KA/Lee KH/Zhang R/Jung MS/Hyun JW
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Abstract
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25-Hydroxycholesterol (cholest-5-ene-3, 25-diol, 25-OHC) showed the cytotoxicity on HeLa human cervix and NCI-H460 human lung cancer cells, 0.5 μM of 50% inhibitory concentration. We studied 25-OHC as the possibility of radiation sensitizer. The combination effect of 25-OHC and γ-irradiation measured using flow cytometer with propidium iodide stained cells. The combined treatment of 25-OHC and γ-irradiation did not show significant enhancing effects on Hela and NCI-H460 cells.
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