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KMID : 0382320050250030087
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Environmental Mutagens and Carcinogens
2005 Volume.25 No. 3 p.87 ~ p.96
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Tumor suppressor p16^(INK4a) in Cancer
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이미현/Lee MH
최부영/서영준/Choi BY/Surh YJ
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Abstract
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p16^(INK4a) is a tumor suppressor that belongs to the INK4 family of the cyclin D-dependent kinases (cdk) inhibitors. It plays regulatory roles in cell proliferation and in tumorigenesis by interacting with Rb signaling. Abnormally elevated p16^(INK4a) protein expression causes cell cycle arrest (G1/S transition) and loss of cyclincdk activity. In many cancers, p16^(INK4a) is altered by mutation, deletion, and promoter methylation. This review summarizes the function of p16 as an important regulator of cancer pathobiology and a promising target for developing cancer therapeutic and chemopreventive agents.
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KEYWORD
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