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KMID : 0382619810010010361
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Hanyang Journal of Medicine
1981 Volume.1 No. 1 p.361 ~ p.367
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Changes in Activities of Serum and Liver Enzymes in Patients with Liver Disorders
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Abstract
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Activities of glucose-6-phosphatase (G-6-Pase) and alkaline deoxyribonuclease (DNase) were determined in serum and liver tissues obtained from patients with various types of hepatitis in order to compare them with those obtained from. normal persons and relate the activities of serum enzymes to those of hepatic enzymes. Also studied were interrelationship between changes in the serum and hepatic enzyme activities and the degree of liver damage.
(1) While the activity of serum G-6-Pase was. greatly increased, the activity of hepatic G-6-Pase was significantly decreased in the acme phase of acuteviral hepatitis. In the resolving phase of acute viral hepatitis, the activity of hepatic G-6-Pase was significantly decreased, but the activity of serum G-6-Pase was not changed.
(2) In the acme phase of acute viral hepatitis and nonspecific reactive hepatitis the activity of serum alkaline DNase was significantly increased. Whereas the activity of hepatic alkaline DNase was significantly decreased.
(3) The activity of serum GPT was significantly increased in both the acme phase and the resolving phase of acute viral hepatitis and the protein content of the liver was significantly decreased in the acme phase of acute viral hepatitis,
These results suggest that the determinations of the activities of serum G6-Pase and alkaline DNase together with.that of serum GPT could be used for diagnostic measures of the acme phase of acute viral hepatitis and that increase in the activities of serum enzymes may reflect the increased excretion of these enzymes from the damaged hepatocytes into the blood.
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