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KMID : 0382619900100020778
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Hanyang Journal of Medicine
1990 Volume.10 No. 2 p.778 ~ p.786
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Effects of Mannitol-Hypertonic Solution on the Electrophysiological Characteristics of the Rabbit Sinus Node Cell and Gold-fish Atrial Muscle Cell
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Abstract
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The effects of hypertonicitr on the electrical activities of cardiac cells were studied in the rabbit sinus node cell and gold-fish atrial muscle cell. In the rabbit sinus node cell, increased tonicity up to 420mOsm/L resulted in significant increments of the nodal action potential amplitude (APA) and overshoot (OS) potential whereas hypertonicity did not cause any change in maximum diastolic potential (MDP).
Following superfusion of rabbit sinus node cells with mannitol-hypertonic solution, action potential duration (APD_(60): time to 60% repolarization) was significantly prolonged while the rate of spontaneous firing (RSF) was increased markedly.
On the other hand in-creased tonicity up to 470mOsm/L caused a significant deccrease in the RSF of atrial muscles cell in the gold-fish. The results of the present study indicate that electrical activities of animal cardiac cells are altered by hypertonic solution and effect of hypertonicity may not be the same in different species of animals.
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