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KMID : 0385219950050010001
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Korean Journal of Gerontology
1995 Volume.5 No. 1 p.1 ~ p.7
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The Influence of Ginseng on the Aging of Senescence Accelerated Mouse
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Cho Sam-Rae
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Abstract
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The effect of ginseng (Panax ginseng C. A. Meyer) on the aging of senescence accelerated mouse (Sam-P/I)was investigated. Mice were received giseng water extract(25 ㎎/㎏ body weight) together drinking water from 6 months of age until all experiments had been completed. All animals were reared in a clean conventional barrier system under the condition of a 12 hr light/dark cycle, and 20±2℃ in temperature. Ginseng-treated mice showed somewhat high body weight gain in the middle age as compared with tat of control. However, there was no change in the weigh of organs. Mean life span of the mice was not changed by the treatment, but that of final 10% mice showed a slight prolonged longevity of serum glucose and total cholesterol was decreased slightly by ginseng treatment, but triglyceride and uric acid content was increased. Serum antioxdant capacity against autoxidation of ox brain homogenates was higher in the ginseng treated mice than in control ones, but the content of thiobarbituric acid-reactable substance showed no change. Activities of liver cytosolic superoxide dismutase and glutathione peroxidase were not significantly changed, however, levels of cytochrome P-450 and NADPH cytocrome p-450 reeducate were remarkably increased by the treatment of ginseng extract. These results suggest that long-term administration of SAM-P/1 mice with ginseng extract enhances their serum antioxidnt activity and liver detoxification capability associated with P-450, which might be contributed to the retarding the age related deterioration of physiological function.
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KEYWORD
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aging, ginseng, antioxiant activity, senobiltic metabolism
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