|
KMID : 0385219950050020117
|
|
Korean Journal of Gerontology
1995 Volume.5 No. 2 p.117 ~ p.121
|
|
|
Effect of Docosahexaenoic acid(DHA)-Rich Fish Oil on Experimental Induced Dementia, Alzheimer-Type 2. Effect of DHA on Reactive Oxygen Species and Their Scavenger Enzymes in Rabbits
|
|
Choi Jin-Ho
Kim Dong-Woo
Moon Young-Sil
Kim Yong-Sun
Kim Jae-Il
|
|
|
Abstract
|
|
|
|
New Zealand white rabbits were fed commercial basic diets, and administered orally 5.0% and 10% of docosahexaenoic acid(DHA)-rich fish oil including 31.95% of DHA for DHA-5 and DHA-5 and DHA-10 groups for 80 days, and experimental Alzheimer’s diseases were induced with injection of 1.0% aluminum chloride. Malondiadehyde(MDa)levels in serum of rabbits in pre-aluminum injection were significantly increased were rather higher in post-aluminum injection than in pre-aluminum injection, but significant difference between them could not be obtained. Lipofuscin formation resulted in a marked inhibitions of 65-70% in DHA-5 and DHA-10 groups compared with control group (p<0.001). Formations of reactive oxygen species(ROS) such as hydroxyl radical and hydrogen peroxide in brain micresomes of Alzheimer’s-induced rabbits were significantly inhibited in DHA-rich fish oil groups, but significant difference between these ROS formations in brain mitochondria of DHA-administered groups could not be obtained. Superoxide dismutase(SOD) and gluthione peroxidase(GSH-PX) activities as scavenger enzyme on ROS were significantly increased in brain mitochondria and in brain cytosol of DHA-administered groups, respectively. These results suggest that strong toxicity of 1.0% aluminum chloride injected for induction of Alzheimer’s disease in rabbits could be decreased with administration of DHA-rich fish oil.
|
|
|
KEYWORD
|
|
|
Alzheimer’s-type dimentia, docosahexaenoic acid(DHA), reactive oxygen species(ROS), hydroxyl radical, superoxide dismutase(SOD), glutathione peroxidase(GSH-PX)
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|