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KMID : 0385219960060030020
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Korean Journal of Gerontology
1996 Volume.6 No. 3 p.20 ~ p.24
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Effect of Docosahexaenoic Acid (DHA) on Learning and Memory Impairment Animal Model SAMP8 - Ⅱ. Feeding Effect of DHA on Oxygen Radicals and Their Scavenger Enzymes of SAMP8 Brain
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Choi Jin-Ho
Kim Dong-Woo
Kim Jae-Il
Han Sang-Seop
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Abstract
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Technology this study was designed to investigate the effects of docosahexaenoic acid (DHA)-rich fish oil on oxygen free radicals and their scavenger enzymes of learning and memory impairments SAMP8. SAMP8 were fed basic diets(control group) with 15% of lard, and experimental diets (DHA group) with 5.0% of lard and 10% of docosahexaenoic acid (DHA)-rich fish oil (31.95% of DHA) for 8 months. Hydroxyl radical formations in DHA group were significantly inhibited about 15%, but superoxide radical and hydrogen peroxide formations in DHA group were remarkably increased about 80% and 20%, respectively, compared with control group. Lipid peroxide (LPO) contents in brain mitochondria fraction were significantly inhibited to 20% by long-term administration of DHA-rich fish oil. Supeoxide dismutase (SOD) and glutathione peroxidase (GSHPx) activities of brain cytosol fraction in DHA group were significantly higher (15% and 40%, respectively) than those in control group. These results suggest that the damages of brain cells, and learning and memory impairments SAMP8 may be effectively inhibited by long-term administration of DHA-rich fish oil.
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KEYWORD
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Senescence-accelerated mouse (SAM), Docosahexaenoic Acid (DHA), Reactive oxygen species (ROS), Lipid peroxide (LPO), Scavenger enzymes, Superoxide dismutase (SOD), Glutathione peroxidase (GSHPx)
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