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KMID : 0385219960060030048
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Korean Journal of Gerontology
1996 Volume.6 No. 3 p.48 ~ p.53
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Protective Effect of Melanoidins on oxidative stress in neural cells
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Im Won-Yong
Moon Gap-Soon
Kim Jeong-Sang
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Abstract
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There is an increasing amount of evidence that oxidative stress is a major cause of many chronic diseases including neurodegenerative disorders, cancer, and heart diseases. The brain consumes an excessive amount of the body’s oxygen, as it derives its energy mainly from oxidative metabolism of the mitochondrial respiratory chain. The leakage of high energy electrons along the mitochondrial electron transport chain leads to formation of superoxide anion(O2) and hydrogen peroxide(H2O2) which are detrimental to the neuronal cells. melanoidins, the final products of Maillard reaction, is well known for their in vitro antioxidative activity. In this study we examined the effect of melanoidins on oxidative stress generated by paraquat and hydrogen peroxide against neural cells in culture model system. Three kinds of melanoidins were prepared from glucose-glycine, glucose-lysine and xylose-arginine, and their antioxidative activities were tested for human nueroblastoma cells. Melanoidins significantly suppressed the cytotoxic effect of paraquat and hydrogen peroxide toward human neuroblastoma cells shile xylose-arginine melanoidin was the most effective. Melanoidins also reduced hydroperoxide formation in the cells insulted with paraquat of hydrogen peroxide, suggesting protective effect of melanoidins from cellular oxidative damage. The preventive effect of melanoidins was further confirmed by the observation that PCOOH contents in cells treated with paraquat or hydrogen peroxide were greatly reduced by melanodins.
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KEYWORD
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melanoidins, antioxidative effect, neural cells
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