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KMID : 0385219970070020084
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Korean Journal of Gerontology
1997 Volume.7 No. 2 p.84 ~ p.89
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Age-Related Changes in Xenobiotic Metabolizing Enzymes in the Liver of Senescence Accelerated Mice Age-Related Changes in Xenobiotic Metabolizing Enzymes in the Liver of Senescence Accelerated Mice
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Sohn Hyung-Ok
Lim Heung-Bin
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Abstract
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Liver microsomal mixed funtion oxidase (MFO) and its related enzymes were investigated in senescence resistant mice (SAMR1) and senescence accelerated mice (SAMP1) relative to age. The ratio of liver to body weight, and the amount of soluble protein in the microsomal fraction of the liver were not changed with age in either of the studied groups. Levels of cytochrome P-450 and NADPH cytochrome P-450 reductase were not also significantly changed with age, and there was no significant change between the two groups Activities of P-450-dependent monooxygenase such as arylhydrocarbon hydroxylase, 7-ethoxycoumarine O-deethylase, benzphetamine N-demethylase, aniline hydroxylase and ethoxyresorufin O-deethylase were not significantly changed. The activity of NADH cytochrome b5 reductase increased significantly with age only in SAMP1 mice. These results suggest that microsomal MFO activity of SAM mice is not altered even though the aging process is accelerated by a genetic deficit. The increased levels of cytochrome b5 and NADH cytochrome b5 reductase may be attributed, not to the MFO system as an electron transfer system, but to another biochemical system such as the system that catalyzes various types of fatty acid desaturation reactions.
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KEYWORD
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Aging, Xenobiotic Metabolizing Enzymes, SAM
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