|
KMID : 0385219970070030092
|
|
Korean Journal of Gerontology
1997 Volume.7 No. 3 p.92 ~ p.97
|
|
|
Effects of aging and dietary restriction on free radical generation and GSH/GSSG level in rat testis
|
|
Kang Hyun-Kyung
Noh Jae-Kyung
Soung Do-Yu
Kim Nam-Deuk
Choi Won-Cheol
Lim Woon-Ki
Yu Byung-Pal
Chung Hae-Young
|
|
|
Abstract
|
|
|
|
This study was performed to elucidate the effect of aging and dietary restriction on free radical generation, GSH level and GSH/GSSG ratio in rat testis. Free radical generation, thiobarbituric acid-reactive substance(TBARS), GSH and GSH/GSSG were assayed in 6, 12, 18 and 24 months of age which were ad-libitum fed or diet-restricted. Free radical generation and TBARS increased, but GSH level and GSH/GSSG ration decreased with age ad-libitum group. However, in diet-restricted group, Free radical generation and TBARS were maintained lower than 6 months of ad-libitum, and GSH and GSH/GSSG ration were higher than that of ad-libitum. These results suggest that dietary restriction might maintain the reproductive ability by reducing free radical tree radical generation and lipid peroxidation and maintaining the GSH level in rat testis.
|
|
|
KEYWORD
|
|
|
Free radical, Dietary restriction, Agino, Glutathione(GSH), Lipid peroxidation, Testis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|