|
KMID : 0385219990090020050
|
|
Korean Journal of Gerontology
1999 Volume.9 No. 2 p.50 ~ p.53
|
|
|
Calbindin D-28k Immunoreactive Neurons in the Main Olfactory Bulb of Adult and Aged Rats
|
|
Kang Tae-Cheon
Lee Jae-Chul
Choi Ki-Yong
Park Seung-Kook
Won Moo-Ho
|
|
|
Abstract
|
|
|
Although it is well established that calbindin D-28k plays an important role in mammalian olfactory systems the age-related changes of its immunoreactivity are not manifested. Thus, we investigated the changes of calbindin D-28k immnoreactive neurons in the main olfactory bulb of adult and aged rat brains using immunohistochemistry. In the main olfactory bulb of adult and aged rats, the localization of calbindin D-28k immnoreactive neurons was almost restricted to the glomerular layer of the main olfactory bulb. However, a few calbindin D-28k immnoreactive neurons were observed in the granular layer of the main olfactory bulb. In the adult rat, many calbindin D-28k immnoreactive neurons were found in the main olfactory bulb, and the morphology of calbindin D-28k immnoreactive neurons had long processes. In the aged rat, compared to the adult rat, the morphology of calbindin D-28k immnoreactive neurons showed the tendency to decrease their neuronal sizes and the number of dendrites without reduction of neuronal population. The distinct reduction of calbindin D-28k immnoreactive neuronal dendrites in glomeruli may be due to the age-related functional restrictions.
Therefore, the declines of calbindin D-28k immnoreactive neurons in the glomerular layer by aging suggest salient mechanistic alterations in calcium homeostasis, that may underlie the age-related changes in the olfactory processes.
|
|
|
KEYWORD
|
|
|
Calbindin D-28k, Olfactory bulb, Adult and Aged Rats Immunohistochemistry
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|