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KMID : 0385219990090030028
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Korean Journal of Gerontology
1999 Volume.9 No. 3 p.28 ~ p.33
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A Study on the Effect of Methanol Extract of Trichosanthes kirilowii on the Accumulation of Cadmium in Rats(Ⅰ)
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Lee Jong-Sub
Yoo Il-Soo
Kim Jong-Soo
Lee Ki-Nam
Kang Kil-Ung
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Abstract
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This study was conducted to investigate the antitoxic component in the methanol extract of Trichosanthes kirilowii. The results were as follows : Generally, detoxication effect by Trichosanthes kirilowii extract increased in proportion to the extract concentrations. When 40㎎/㎏ dosage of Trichosanthes kirilowii extract was administered, it showed the highest antitoxic effects in metallothionein induction. After the extract treatment, body weights increased in proportion to extract concentration. From the above results, Trichosanthes kirilowii extract increased metalothionein concentration and decreased the toxicity of cadmium in rat.
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KEYWORD
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Trichosanthes kirilowii, Antitoxic agent, Cadmium, Rat, Metallothionein
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