KMID : 0387820070140020167
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Clinical Pediatric Hematology-Oncology 2007 Volume.14 No. 2 p.167 ~ p.175
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Outcome of Multicenter Study for Korean Children with Medulloblastoma
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Park Hyun-Jin
Baek Hee-Jo Seo Jong-Jin Suh Chang-Ok Sung Ki-Woong Shin Hyoung-Jin Ahn Seung-Do Ahn Hyo-Seop Wang Kyu-Chang Yoo Keon-Hee Ryu Kyung-Ha Yoo Eun-Sun Lyu Chuhl-Joo Lee Kun-Soo Lee Soon-Yong Lee Young-Ho Lee Jun-Ah Lim Do-Hoon Im Ho-Jun Chung Nak-Gyun Jeong Dae-Chul Jung Hye-Lim Cho Byung-Kyu Cho Bin Choi Eun-Jin Choi Joong-Uhn Hwang Tae-Ju Nam Byung-Ho Lim Hyun-Sun Shin Hee-Young Hah Jeong-Ok Kang Hyuoung-Jin Koo Hong-Hoe Kook Hoon Kim Dong-Seok Kim Seung-Ki Kim Il-Han Kim Ji-Yoon Ghim Thad T. Kim Hack-Ki Kim Heung-Sik Ra Young-Shin Moon Hyung-Nam Park Kyung-Duk Park Byung-Kiu Park Sang-Kyu Park Jun-Eun Park Ji-Kyoung
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Abstract
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Purpose: Medulloblastoma is the most common primary malignant brain tumor of childhood. In spite of improved multimodality approach, 30¡40% of children with medulloblastoma still suffer from recurrence. Furthermore, many survivors have significant long-term sequelae. This study was undertaken to investigate the current status of childhood medulloblastoma in Korea.
Methods: Questionnaires were sent to the member hospitals of the Korean Society of Pediatric Neuro-Oncology. One hundred and sixty seven cases from 20 university hospitals were collected and analyzed.
Results: The median age at diagnosis was 6.9 years and the male to female ratio was 1.9£º1. Patients in average risk group were 77 (46%) and those in high risk group were 90 (54%). In average risk group, 1 patient was treated with operation only, 4 were treated with operation and radiotherapy, 70 were treated with operation, radiotherapy and chemotherapy, 2 were treated with various treatments. In high risk group, 4 patients were treated with operation and radiotherapy, 9 were treated with operation and chemotherapy, 58 were treated with operation, radiotherapy and chemotherapy, 16 were treated with high dose chemotherapy and autologous stem cell rescue, and 3 were treated with various treatments. Median follow up was at 30.8 months, and 3 year EFS was 65% for all patients. The 3 year EFS were 78% for patients in average risk group and 54% for patients in high risk group.
Conclusion: Diverse treatment protocols have been applied for childhood medulloblastoma in Korea. This study inspired the necessity of nation-wide protocols and prospective multicenter studies for medulloblastoma in Korea.
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KEYWORD
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Medulloblastoma, Children, Treatment, Korea
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