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KMID : 0388220130200050218
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Journal of the Korean Rheumatism Association
2013 Volume.20 No. 5 p.218 ~ p.222
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Application of Induced Pluripotent Stem Cells in Rheumatology
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Jung Seung-Min
Ju Ji-Hyeon
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Abstract
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Since induced pluripotent stem cell (iPSC) was first in-troduced by Yamanaka in 2006, it took only six years to win a Nobel Prize for his pioneering work. It is unusual to win a Nobel Prize for such recent research with a short history. Many scientists and clinicians are interested in iPSC for its potential application. Significant progression in this field has been made, while there remain many hurdles to overcome for application of iPSC technique in real clinics. In this re-view, the concept of reprogramming and the basic techni-ques of iPSC generation will be discussed for the reader’s convenience, followed by discussion of recent progress, fol-lowed by the topics of "disease modeling" and "cell therapy" with iPSC in the second half of this article. Several examples of rheumatologic application of iPSC will be provided in the main text. If rheumatologists could understand the merits and potentials of iPSC, opportunities for innovative research and therapy can be expanded.
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KEYWORD
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Induced pluripotent stem cell , Rheumatoid ar-thritis , Osteoarthritis , Fibroblast like synoviocyte , Lentivi-rus , Reprogramming
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