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KMID : 0388220130200050314
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Journal of the Korean Rheumatism Association
2013 Volume.20 No. 5 p.314 ~ p.318
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Exacerbation of Lupus Nephritis in Pregnant Women with Remission of Lupus Nephritis
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Jeon Ja-Young
Suh Chang-Hee
Kim Hyoun-Ah
Jung Ju-Yang
Lee Joo-Ho
Kang Eun-jung
Yim Hyun-Ee
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Abstract
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Systemic lupus erythematosus (SLE) is a multisystem auto-immune disorder that predominantly affects women of re-productive age. Risk of SLE flare during pregnancy is de-pendent on disease activity of SLE and proteinuria at the time of conception, which affect pregnancy outcome. We report on three patients who developed renal flares during pregnancy after remission of lupus nephritis before pregnancy. Two patients were treated successfully, with pregnancy outcomes of live births however, another pa-tient’s pregnancy was terminated with induced abortion. For SLE patients, family planningis needed until disease activity of SLE has been stable for at least six months pri-or to the pregnancy. Nevertheless, flares of lupus could de-velop and influence maternal and fetal outcome. There-fore, renal flares during pregnancy should be recognized and treated immediately.
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KEYWORD
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Systemic lupus erythematosus , Nephritis , Pregnancy , Flare , Abortion
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