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KMID : 0388220140210040182
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Journal of the Korean Rheumatism Association
2014 Volume.21 No. 4 p.182 ~ p.186
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Human Leukocyte Antigen-DRB1 Associations in Korean Juvenile Rheumatoid Arthritis
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Lee Chan-Jae
Sohn Tae-Young
Lee Dae-Hyoung
Lee Hae-Ran
Kim Mi-Young
Kim Kwang-Nam
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Abstract
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Objective: The aim of this study is to investigate the associ-ation of different subgroups of juvenile rheumatoid arthri-tis (JRA) with human leukocyte antigen (HLA) class II DR alleles.
Methods: One hundred and nineteen Korean juvenile rheu-matoid arthritis patients were classified as HLA-DRB1 allele. To assess the frequency, phenotype frequencies of all JRA cases and each subtypes were compared to those of 485 adult controls.
Results: HLA-DRB1*01 was associated with increased risk of JRA. Furthermore, DRB1*01 was associated with poly-articular JRA and pauciarticular JRA. The frequencies of DRB1*14 and DRB1*15 were higher in systemic JRA pa-tients than the controls.
Conclusion: The data of this study on Korean children with JRA suggests that HLA-DRB1*01 was associated with the susceptibility of JRA. The study should be ex-tended to include larger numbers of patients.
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KEYWORD
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Juvenile rheumatoid arthritis, Human leuko-cyte antigen, HLA-DRB1
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