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KMID : 0390320080180020424
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Chungbuk Medical Journal
2008 Volume.18 No. 2 p.424 ~ p.431
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Effects of Alkoxyglycerol on the IL-12, IFN-γ and TNF-α Expression in Human
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Kim Yong-Dae
Kim Heon
Hong Jang-Soo
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Abstract
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Purpose: It is known that alkoxyglycerol can affect immune function in human. A randomized, double blind, placebo-controlled human intervention study involving 69 healthy volunteers (23 men and 46 women) was performed to investigate the effect of alkoxyglycerol on the IL-12, IFN-γ and TNF-α expression in human.
Materials and Methods: Volunteers were recruited and randomly distributed into two groups, one receiving an alkoxyglycerol (13.5 g/day) and the other a placebo orally for 10 weeks. IL-12, IFN-γ, and TNF-α were evaluated before and after 10-week alkoxyglycerol intake.
Results: Sixty subjects were finally succeeded in 10 weeks courses. The changes of expression levels of IL-12, INF-γ, and TNF-α were not statistically significant between alkoxyglycerol and placebo groups.
Conclusion: This result suggests that administration of alkoxyglycerol intake may not affect the expressions of IL-12, INF-γ, and TNF-α in human. Further study needs to evaluate the other immunological markers.
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KEYWORD
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alkoxyglycerol, IL-12, INF-γ, TNF-α, Clinical trial
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