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KMID : 0390320130230020035
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Chungbuk Medical Journal
2013 Volume.23 No. 2 p.35 ~ p.44
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Clinical significance of Hypercalciuria and Hyperuricosuria in Adult Patients with Asymptomatic Microscopic Hematuria
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Lee Shin-Young
Kwon Soon-Kil
Kim Hye-Young
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Abstract
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Purpose: Hypercalciuria and hyperuricosuria are causes of hematuria in children. It is not definite that hypercalciuria or hyperuricosuria is a cause of hematuria in adult patients. This study was conducted to determine the clinical significance of hypercalciuria and hyperuricosuria in adult patients with asymptomatic microscopic heamturia.
Materials and Methods: Total of 283 patients with microscopic hematuria were devided into two groups, normocalciuria and hypercalciuria group. We compared clinical characteristics, laboratory findings and imaging studies between the two groups. Also the total of 283 patients were divided into two groups according to presence of hyperuricosuria. In patients with either hypercalciuria or hyperuricosuria, laboratory studies were followed up.
Results: Among total of 283 patients, there were 29(10.2%) hypercalciuria and 47(16.6%) hyperuricosuria patients. There were no significant difference in average age, serum creatinine, urine RBC, urine protein, urine dysmorphic RBC, complement, IgA and FANA. Urine uric acid in hypercalciuria patients was significantly increased compared to normocalciuria patients(558.84±198.03 mg/day vs. 766.00±233.64 mg/day, p<0.001) and urine calcium in hyperuricosuria group was significantly increased compared to normouricosuria patients(141.73±77.36 mg/day vs. 222.20±84.89 mg/day, p<0.001). In hypercalciuria group, hematuria was disappeared in 5(25.0%) out of 20 patients who undergone urinalysis follow-up, and in hyperuricosuria group, 9(26.5%) out of 34 have recovered from hematuria.
Conclusion: In adult asymptomatic microscopic hematuria patients, the prevalence of hypercalciuria and hyperuricosuria were significantly high. On follow-up urinalysis, hematuria was disappeared in a small portion of hypercalciuria and hyperuricosuria patients. The urinary calcium and uric acid may be useful for differential diagnosis of adult patients with asymptomatic microscopic hematuria
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KEYWORD
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Microscopic hematuria, Hypercalciuria, Hyperuricosuria
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