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KMID : 0390320230330010023
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Chungbuk Medical Journal
2023 Volume.33 No. 1 p.23 ~ p.28
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Thrombopoietin receptor agonists induced myelofibrosis: A case report and review of literatures
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Park Hee-Sue
Son Bo-Ra
Kwon Ji-Hyun
Lee Nu-Ri
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Abstract
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Bone marrow myelofibrosis is caused by abnormal proliferation of collagen and reticulin, which make up the structural fibrosis in bone marrow microenvironment. It is one of the major criteria for the diagnosis of primary myelofibrosis in WHO 2016 classification, and it is important to confirm clonality through the detection of additional genetic aberration. If not, differentiation from secondary fibrosis caused by other causes is necessary. The authors report a case of secondary fibrosis that occurred after administration of eltrombopag and romiplostim, a thrombopoietin receptor agonist, to a 34-year-old female patient diagnosed with immune thrombocytopenia, along with a literature review.
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KEYWORD
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myelofibrosis, myeloproliferative neoplasm, eltrombopaq, romilostim, thrombopoietin receptor agonist
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