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KMID : 0425119990370020093
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Parasites, Hosts and Diseases
1999 Volume.37 No. 2 p.93 ~ p.99
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Eosinophil and IgE responses of IL-5 transgenic mice experimentally infected with Nippostrongylus brasiliensis
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Jong Til CHAI
Eun Hee SHIN/Kiyoshi TAKATSU/Naoki MATSUMOTO/Somei KOJIMA/Jong Til CHAI/Eun Hee SHIN/Kiyoshi TAKATSU/Naoki MATSUMOTO
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Abstract
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Eosinohil and IgE responses of interleukin IL(-5 transgenic and normal C3H/HeN mice were studied after experimental infection with Nippostrongylus brasiliensis 9Nb). Intestinal worms were recovered at day 5 post-infection (PI), and numbers of total white blood cells (WBC) and eosinophils, and total serum IgE and anti-hapten (dinitrophenyl)(DNP) specific IgE titers, were measured at days 0,14 and PI. IL-5 mice appeared resistant to Nb infection showing a significantly ower worm recovery rate than normal mice (P<0.05). Total WBC and eosinophil counts (/mm3) were significantly increased in Nb infected normal mice (p<0.05), but unchanged (total WBC) or decreased (eosinophils) in IL-5 mice at day 21 PI. The total serum IgE level remarkably increased in normal mice, but only a little in IL-5 mice at days 14 and 21 PI. Priming with DNP brought about more remarkable increases of the total and anti-DNP specific IgE in normal mice than in IL-5 mice. The results show that IL-5 mice are resistant to Nb infection, and that eosinophil and IgE responses in these mice are not augmented by N infection.
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KEYWORD
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Nippostrongylus brasiliensis, IL-5 transgenic mice, eosinophils, IgE, worm recovery,
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