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KMID : 0425120090470030299
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Parasites, Hosts and Diseases
2009 Volume.47 No. 3 p.299 ~ p.302
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Imported Malaria in Korea: a 13-Year Experience in a Single Center
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Cheong Hae-Suk
Kwon Ki-Tae
Rhee Ji-Young
Ryu Seong-Yeol
Jung Dong-Sik
Heo Sang-Taek
Shin Sang-Yop
Chung Doo-Ryun
Peck Kyong-Ran
Song Jae-Hoon
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Abstract
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The incidence of imported malaria has been increasing in Korea. We reviewed data retrospectively to evaluate the epidemiology, clinical features, and outcomes of imported malaria from 1995 to 2007 in a university hospital. All patients diagnosed with imported malaria were included. Imported malaria was defined as a positive smear for malaria that was acquired in a foreign country. A total of 49 patients (mean age, 35.7 year; M : F = 38 : 11) were enrolled. The predominant malarial species was Plasmodium falciparum (73.5%), and the most frequent area of acquisition was Africa (55.1%), followed by Southeast Asia (22.4%) and South Asia (18.4%). Fourteen-patients (30.6%) suffered from severe malaria caused by P. falciparum and 1 patient (2.0%) died of multiorgan failure. Most of the patients were treated with mefloquine (79.2%) or quinine (10.2%); other antimalarial agents had to be given in 13.2% treated with mefloquine and 44.4% with quinine due to adverse drug events (ADEs). P. falciparum was the most common cause of imported malaria, with the majority of cases acquired from Africa, and a significant number of patients had severe malaria. Alternative antimalarial agents with lower rates of ADEs might be considered for effective treatment instead of mefloquine and quinine.
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KEYWORD
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Plasmodium, imported malaria, adverse drug events, mefloquine, quinine
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