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KMID : 0425120120500040301
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Parasites, Hosts and Diseases
2012 Volume.50 No. 4 p.301 ~ p.308
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Experimental Murine Fascioliasis Derives Early Immune Suppression with Increased Levels of TGF-β and IL-4
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Chung Joon-Yong
Bae Young-An
Yun Doo-Hee
Yang Hyun-Jong
Kong Yoon
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Abstract
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In fascioliasis, T-helper 2 (Th2) responses predominate, while little is known regarding early immune phenomenon. We herein analyzed early immunophenotype changes of BALB/c, C57BL/6, and C3H/He mice experimentally infected with 5 Fasciola hepatica metacercariae. A remarkable expansion of CD19+ B cells was observed as early as week 1 post-infection while CD4+/CD8+ T cells were down-regulated. Accumulation of Mac1+ cells with time after infection correlated well with splenomegaly of all mice strains tested. The expression of tumor necrosis factor (TNF)-α mRNA in splenocytes significantly decreased while that of IL-4 up-regulated. IL-1β expression was down-modulated in BALB/c and C57BL/6 mice, but not in C3H/He. Serum levels of transforming growth factor (TGF)-β were considerably elevated in all mice during 3 weeks of infection period. These collective results suggest that experimental murine fascioliasis might derive immune suppression with elevated levels of TGF-β and IL-4 during the early stages of infection.
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KEYWORD
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Fasciola hepatica, murine fascioliasis, Mac 1+ cell, T-lymphocyte, IL-4, TGF-β
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