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KMID : 0545119960060050366
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Journal of Microbiology and Biotechnology
1996 Volume.6 No. 5 p.366 ~ p.367
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Inhibition Mode of DNA Topoisomerase by Dibutyl Phthalate
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Lee Dong-Sun
Hong Soon-Duck
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Abstract
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Dibutyl phthalate induced topoisomerase Ⅰ mediated DNA relaxation comparable to that of camptothecin, and topoisomerase Ⅱ mediated DNA relaxation equipotent to that of 4´-(9-acridinylamino) methanesulfon-m-anisidide (m-AMSA). The relaxation activities of dibutyl phthalate were dose-dependent and nearly as potent as those of camptothecin and m-AMSA.
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