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KMID : 0545119990090020147
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Journal of Microbiology and Biotechnology
1999 Volume.9 No. 2 p.147 ~ p.149
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Involvement of Cytochrome P450 in(-)-(4R)-Isopiperitenone Oxidation by Cell Suspension Cultures of Mentha piperita
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Park, Si Hyung
Chang, Yung Jin/Kim, Kyung Hyun/Kim, Soo Un
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Abstract
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Biotransformation of exogenous (-)-(4R)-isopiperitenone in cell suspension cultures of Mentha piperita resulted in oxidized products, with (-)-7-hydroxyisopiperitenone being the major compound. The mass of products obtained under ^18O^2 atmosphere was two units higher than that under normal atmosphere. The biotransformation was inhibited by several cytochrome P450-specific inhibitors as well as by carbon monoxide. Carbon monooxide inhibition was substantially overcome by irradiation of cells with blue light including light at 450 nm wavelength. These results suggested that a cytochrome P450-type monooxygenase was involved in the biotransformation.
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