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KMID : 0545120070170091491
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Journal of Microbiology and Biotechnology
2007 Volume.17 No. 9 p.1491 ~ p.1497
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Anti-inflammatory Effects of Recombinant Arginine Deiminase Originating from Lactococcus lactis ssp. lactis ATCC 7962
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Kim Jong-Eun
Hur Haeng-Jeon
Lee Ki-Won
Lee Hyong-Joo
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Abstract
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Arginine deiminase (ADI, E.C. 3.5.3.6), one of the arginine deprivation enzymes, exhibits anticarcinogenic activities. The present study investigated the anti-inflammatory activities of the purified recombinant ADI originating from Lactococcus lactis ssp. lactis ATCC7962 (LADI). LADI dose-dependently inhibited lipopolysaccharide (LPS)-induced upregulation of inducible nitric oxide synthase and the production of nitric oxide in RAW 264.7 murine macrophages. The induction of cyclooxygenase-2 expression and subsequent production of prostaglandin E2 by LPS was also attenuated by LADI treatment. Moreover, LADI inhibited the production of interleukin-6 in LPS-stimulated RAW 264.7 macrophages. These results indicate that LADI exerts anti-inflammatory effects, which may in part explain its chemopreventive potential.
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KEYWORD
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Arginine deiminase, lactic acid bacteria, inducible nitric oxide synthase, cyclooxygenase-2, interleukin-6
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