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KMID : 0545120090190040368
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Journal of Microbiology and Biotechnology
2009 Volume.19 No. 4 p.368 ~ p.371
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Aspochalasin I, a Melanogenesis Inhibitor from Aspergillus sp.
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Choo Soo-Jin
Yun Bong-Sik
Ryoo In-Ja
Kim Young-Hee
Bae Ki-Hwan
Yoo Ick-Dong
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Abstract
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In the course of screening for the melanogenesis inhibitors, aspochalasin I was isolated from solid-state culture of Aspergillus sp. Fb020460. Its structure was determined by spectroscopic analysis including mass spectroscopy and NMR analysis. Aspochalasin I potently inhibited melanogenesis in Mel-Ab cells with an IC50 value of 22.4 μM without cytotoxicity.
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KEYWORD
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Melanogenesis, aspochalasin I, Aspergillus sp.
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