|
KMID : 0545120120220070894
|
|
Journal of Microbiology and Biotechnology
2012 Volume.22 No. 7 p.894 ~ p.901
|
|
|
Construction of Novel Bifunctional Chimeric Proteins Possessing Antitumor and Thrombolytic Activities
|
|
Jing Hui
Youjin Dai
Yuanyuan Bian
Hui Li
Xiaojin Cui
Xiaojie Yu
Song You
Fengqing Hu
|
|
|
Abstract
|
|
|
|
Based on their respective antitumor and thrombolytic activities, the superantigen staphylococcal enterotoxin C2 (SEC2) and staphylokinase (Sak) were chosen for the construction of the novel chimeric proteins Sak-linker- SEC2 and SEC2-linker-Sak using a linker composed of nine Ala residues. Both chimeric proteins possessed nearly the same PBMC proliferation stimulating activity and antitumor activity as SEC2 and thrombolytic activity as Sak. Neither the SEC2 or Sak component of each chimeric protein affected the activity of the other component. The results presented in this study provide a possible strategy to prevent and cure tumor thrombus.
|
|
|
KEYWORD
|
|
|
Chimeric protein, Anti-tumor, Thrombolytic, Staphylokinase, Staphylococcal enterotoxin C2
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|