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KMID : 0545120130230020156
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Journal of Microbiology and Biotechnology
2013 Volume.23 No. 2 p.156 ~ p.160
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Effect of Cordycepin on the Expression of the Inflammatory Cytokines TNF-alpha, IL-6, and IL-17A in C57BL/6 Mice
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Seo Min-Jeong
Kim Min-Jeong
Lee Hye-Hyeon
Park Jeong-Uck
Kang Byoung-Won
Kim Gi-Young
Rhu En-Ju
Kim Jung-In
Kim Kwang-Hyuk
Jeong Yong-Kee
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Abstract
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Culture supernatants of splenocytes from C57BL/6 mice were exposed to 0.3, 1.0, and 3.0 μg/ml cordycepin plus 3.0 μg/ml lipopolysaccharide (LPS) to investigate the effects of cordycepin (3'-deoxyadenosine) on the production of inflammatory cytokines. Co-administration of 3.0 μg/ml cordycepin with LPS in cultured murine spleen cells significantly diminished the expression of the inflammatory cytokines tumor necrosis factor-α and interleukin-6 (IL-6) in a time-dependent manner. Expression of the inflammatory cytokine IL-17A was substantially down-regulated in a time- dependent manner at all cordycepin concentrations. These findings suggest that cordycepin down-regulates the immediate hypersensitivity reaction stimulated by LPS.
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KEYWORD
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Cordycepin, IL-17A, IL-6, splenocytes, TNF-α
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