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KMID : 0603820170230010034
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Journal of Experimental & Biomedical Science
2017 Volume.23 No. 1 p.34 ~ p.38
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Hypocholesterolemic Effect of Tartary Buckwheat (F. tataricum Gaertn.) Extract from High Fat Diet Mice
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Lee Sung-Gyu
Lee Dong-Sup
Kang Hyun
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Abstract
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To investigate the efficacy of extract of Tartary buckwheat (F. tataricum Gaertn.) in high fat diet (HFD) in mice, the F. tataricum Gaertn. extract (FTE) was orally administered to mice with a HFD at 300 mg/kg/day for 4 weeks. Our results show that FTE significantly inhibited fat accumulation. Moreover, FTE markedly reduced the final body weight with a decrease in epididymal adipose tissue mass and adipocyte size compared with the untreated HFD-induced group. Additionally, FTE ameliorated serum total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels. The results show that Tartary buckwheat possesses hypocholesterolemic effect through downregulating lipid metabolism. Further studies are required in this area to strengthen the anti-obesity effects of FTE with active component, and it can be used a pro-drug instead of whole extract.
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KEYWORD
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Tartary buckwheat , Hypocholesterolemic , Lipid Metabolism , High fat diet Mice
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