KMID : 0605620170240010032
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Journal of Korean Society of Biological Psychiatry 2017 Volume.24 No. 1 p.32 ~ p.38
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The Relationship between the Amisulpride-Induced Hyperprolactinemia and Taq1A Polymorphism of the Dopamine D2 Receptor Gene in Schizophrenia Patients
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Kim Jae-Jun
Seo Min-Jae Choi Tae-Young Lee Jong-Hun
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Abstract
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Objectives : This study was aimed to investigate the association between amisulpride-induced hyperprolactinemia and the Taq1A polymorphism in the D2 dopamine receptor gene (DRD2) in schizophrenic patients.
Methods : The plasma concentrations of prolactin were measured before and after treatment with amisulpride in one hundred and twenty-five schizophrenic patients. The effect of the Taq1A variants of the DRD2 on the risk of amisulpride-induced hyperprolactinemia was the main the outcome measure. The genotyping for Taq1A (rs1800497) polymorphism was performed using TaqMan single nucleotide polymorphism (SNP) genotyping assay.
Results : There was a significant difference between the prolactin level at baseline and the 6th week after treatment with amisulpride in all the subjects. However, there were no significant correlations between ¥ÄProlactin (the difference between prolactin level at baseline and the 6th week after treatment) and the Taq1A genotypes.
Conclusions : This is the first study to investigate the-correlations between the Taq1A polymorphism and the amisulpride-induced hyperprolactinemia in Korean schizophrenic patients. The current results suggested the further large-scale researches on various SNPs in the DRD2 gene will establish clear goals and provide answers to the unanswered questions described in this study.
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KEYWORD
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Amisulpride, DRD2 gene, Polymorphisms, Hyperprolactinemia
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