KMID : 0605720220280030098
|
|
Journal of the Korean Society of Biological Therapies in Psychiatry 2022 Volume.28 No. 3 p.98 ~ p.108
|
|
Clinical Factors Related to Change of Depression Severity in Major Depressive Disorder Through Index Electroconvulsive Therapy
|
|
Yang Jae-Won
Kim Yang-Tae Kim Hee-Cheol Jung Sung-Won Lee Ho-Jun
|
|
Abstract
|
|
|
Objectives£ºThe aim of this study was to investigate the factors associated with changes in depression severity in index electroconvulsive therapy (ECT) for major depressive disorder.
Methods£ºA retrospective analysis was performed on 80 patients with major depressive disorder who received index ECT. The severity of depression was assessed using the Hamilton depression rating scale-17 (HDRS-17). Multiple linear regression analysis and logistic regression analysis were performed to identify the factors associated with the change of depression severity and the predictors of the 50% or greater reduction rate of HDRS-17.
Results£º55 (68.8%) patients were HDRS-17 score change ¡Ã50% group, and 25 (31.2%) patients were HDRS-17 score change <50% group. HDRS-17 score change ¡Ã50% group had a shorter episode duration before ECT (11.91¡¾8.63 vs 17.68¡¾11.15 weeks, p=0.027) and more ECT sessions (8.60¡¾2.91 vs 6.80¡¾3.34 sessions, p=0.017). The higher baseline score of anxiety (B=0.937, ¥â=0.374, p<0.001), depression (B=0.846, ¥â=0,324, p=0.001), and somatic symptom (B=0.995, ¥â=0.210, p=0.031) dimensions was associated with the change of HDRS-17 score from baseline. The longer episode duration until the start of ECT was associated with lower likelihood of HDRS-17 score change ¡Ã50% (Wald ¥ö2=7.74, OR=1.08, 95% CI: 1.02-1.14, p=0.005). The greater number of ECT sessions predicted the HDRS-17 score change ¡Ã50% (Wald ¥ö2=7.85, OR=0.75, 95% CI=0.62-0.92, p=0.005).
Conclusions£ºIn higher baseline anxiety, depression, and somatic symptoms severity, implementing sufficient sessions of ECT in pharmacological treatment phase of relatively shorter duration of major depressive episode may help reduce HDRS-17 score.
|
|
KEYWORD
|
|
Electroconvulsive therapy, Major depressive disorder, Depression, Anxiety, Regression analysis
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|