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KMID : 0606620070030010027
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Korean Journal of Fetal Medicine
2007 Volume.3 No. 1 p.27 ~ p.33
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TGF-β1, TGF-β2 and βIGH3 Plasma Levels in Hypertensive and Normotensive Pregnancy
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Lee Jeong-Mi
Park Il-Soo
Koo Tae-Bon
Seong Won-Joon
Kim Mi-Ju
Bae Ji-Hae
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Abstract
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Objective: Isoforms of transforming growth factor-beta (TGF-β1, TGF-β2) are thought to be associated with the
pathogenesis of preeclampsia. We examined if TGF-β1, TGF-β2 and/or βIGH3 are correlated with progress of
hypertensive pregnancy disease.
Methods: The study groups included 35 hypertensive (gestational hypertension=3, mild preeclampsia=6, severe
preeclampsia=20, chronic hypertension=2 and superimposed hypertension=4) and 35 normotensive pregnant women.
Plasma sampling was taken on admission or at outpatient. The quantitative assay of TGF-β1,2 was done with
commercial immunoassay kits and βIGH3 was measured using ELISA.
Results: Plasma TGF-β1 (mean±SD, 0.64±0.98 vs 0.68±0.67 ng/ml, p=0.853) and βIGH3 (341.49±71.35 vs
319.67±63.72 ng/ml, p=0.182) concentrations were not different between two groups. Maternal plasma TGF-β2
(1.16±0.48 vs 0.63±0.26 ng/ml, p<0.001) concentrations were significantly increased in case of hypertensive pregnancy
compared to normotensive.
Conclusion: Our study suggests that TGF-β2 may play a role in the pathogenesis of hypertensive pregnancy, but
TGF-β1 and βigh3 do not seem to be involved.
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KEYWORD
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TGF-β1, TGF-β2, βIGH3, Preeclampsia
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