KMID : 0606920060140020083
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Biomolecules & Therapeutics 2006 Volume.14 No. 2 p.83 ~ p.89
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Different Effects of Flavonoida in Scutellaria baicalensis on Anxious and Sedative Behaviors
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Park Hyung-Geun
Choi Ji-Young Lee Geum-Seon Choi Jong-Hyun Son Kun-Ho Yoon Seo-Young Ko Hong-Sook Ko Kwang-Ho Ryu Jong-Hoon Cheong Jae-Hoon
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Abstract
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The main aim of this study was to characterize the pharmacological profile of flavonoids utilizing behavioral tests and to investigate how the psychopharmacological activities of wogonin, baicalein and oroxylin A are different. Wogonin, baicalein and oroxylin A were intraperitoneally injected as dosages of 2.5, 5, 10 and 20 mg/kg. In the locomotor activity, Rota-rod test, and elevated plus-maze tests, the behavioral parameters were analyzed by automatic systems. Thiopental induced sleeping time was measured. Water extract of S. baicalensis didn¡¯t exhibit sedative effect. Wogonin and bacalein exhibited anxiolytic activity although it was less potent than buspirone. Wogonin and baicalein decreased locomotor activity at a dose of 10 mg/kg. Wogonin also shortened significantly running time on the rota-rod at doses of 5 and 10 mg/kg. Wogonin and baicalein enhanced sleeping at doses of 5 and 10 mg/kg. These results indicate that wogonin produce anxiolysis with sedation and so did bacalein with mild sedation. On the contrary, oroxylin A enganced running activity on the rotarod and did¡¯t depress locomotor activity. Oroxylin A significantly hindered sleeping rather than helped it at doses of 5 and 10 mg/kg. Oroxylin A didn¡¯t produce anxiolysis and instead, produce awakening effect. This study demonstrates that wogonin and bacalein exhibited anxiolytic activity with mild sedation, but oroxylin A didn¡¯t produce anxiolysis and instead, produce awakening effect. This result indicates that anxiolytic effect without sedation induced by Scutellaria baicalensis is produces by combination of flavonoids.
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KEYWORD
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Scutellaria baicalensis, wogonin, baicalen, oroxylin A, sedation, anxiolysis
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