|
KMID : 0606920060140020096
|
|
Biomolecules & Therapeutics
2006 Volume.14 No. 2 p.96 ~ p.101
|
|
|
Green Tea Catechin Causes an Weight Loss in Transgenic Mice Over-expressing Carboxyl Terminus of Amyloid Precusor Protein
|
|
Lim Hwa-J.
Kim Yong K.
Sheen Yhun Y.
|
|
|
Abstract
|
|
|
|
Amyloid β (Aβ) has been reported to have an effect on the induction of oxidative stress that involves the functional and structural abnormalities in Alzheimer’s disease. As a role of e radical scavenger, a green tea treatment was found to have some inhibitory effect on the neurodegenerative process. The aim of this study was to determine if green tea catechin (GTC) reduces in transgenic model. To test this, transgenic mice carrying neuron-specific enolase (NSE) controlled C-terminus (105) of APP (APP-C105) were created and treated them with a low and a high dose of GTC for 6 months. Herein, we concluded that transgenic mice expressing NSE/APP-C105 were successfully created and the GTC-treated group exhibited significant reduction in body weight. Thus, GTC might be a good prevention of obesity or good treatmint for AD patient.
|
|
|
KEYWORD
|
|
|
Alzheimer transgenic, Green tea catechin, Weight loss
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|