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KMID : 0606920060140020102
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Biomolecules & Therapeutics
2006 Volume.14 No. 2 p.102 ~ p.105
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Effects of Psoralen Derivatives on hKv1.5 Current
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Eun Jae-Soon
Kim Dae-Keun
Leem Jae-Yoon
Lee Kyung-A
Park Hoon
Kwon Jin
Jung Young-Hoon
Kwak Yong-Geun
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Abstract
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We examined the effects of psoralen derivatives on a rapidly activating delayed rectifier K+ channel (hKv1.5) cloned from human heart and stably expressed in Ltk- cells. Using the whole cell configuration of the patch-clamp technique, we found that the five psoralen derivatives inhibited hKv1.5 current. Especially, 4-(2-Propenyloxy)-7H-furo[3,2-g][1]benzopyran-7-one (compound 5) was more potent than the inhibition of the hKv1.5 current of psoralen. The compound 5 inhibited the hKv1.5 current in a concentration-, time-, and voltage-dependent manner. These results suggest that the compound 5 is an excellent candidate as an antiarrhythmic drug for atrial fibrillation.
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KEYWORD
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hKv1.5 channel, antiarrhythmic drug, Psoralen derivatives
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