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KMID : 0606920060140020106
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Biomolecules & Therapeutics
2006 Volume.14 No. 2 p.106 ~ p.109
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A Correspondence between Aging-related Reduction of Neprilysin and Elevation of Aβ-42 or y-Secretase Activity in Transgenic Mice Expressing NSE-controlled APPsw or Human Mutant Presenilin-2
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Lim Hwa J.
Kim Yong-K.
Sheen Yhun-Y.
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Abstract
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Neprilysin (Nep) is known to be important to degrade Aβ derived from amyloid precursor protein (APP) by cleavege with β-and y-secretases. In order to determin e whether a correspondence between Aβ-42/y-secretase activity and Nep levels exists in postnatal aging of transgenic mice expressing either neuron-specific enolase (NSE)-controlled human mutant presenilin-2 (hPS2m) or APPsw alone, the levels of Nep expression and Aβ-42/y-secretase activity were examined at age of 5,12,and 20 months, respectively. The levels of Nep expres- sion in both types of transgenic brains were decreased relative to those of control mice in a aging-related manner, while the level of Aβ-42/y-secretase activity was reversibly increased. Thus, changes in Aβ-42 may all reflect variation in amounts of Nep enzyme.
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KEYWORD
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Alzheimer, neprilysin, amyloid, transgenic
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