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KMID : 0606920060140020110
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Biomolecules & Therapeutics
2006 Volume.14 No. 2 p.110 ~ p.113
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Effect of Sarcotride A on Membrane Potential in C6 Glioma Cells
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Lee Yun-Kyung
Liu Yong-hong
Jung Jee-H.
Im Dong-Soon
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Abstract
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We tested effect of sarcotride A, bioactive cyclitol derivative from a marine sponge, on membrane potential in C6 glioma cells. Membrane potential was estimated by measuring fluorescence change of DiBAC-loaded glioma cells. Sarcotride A increased membrane potential in a concentration-dependent manner. We tested effects of pertussis toxin, U73122, EIPA, and Na+-free media on sarcotride A-induced increase of membrane potential to investigate involvement of G proteins, phospholipase C, Na+/H+ exchanger, and Na+ channels. However, we were not able to observe any significant effect of those pharmacological inhibitors, excluding the involvement of the molecules as candidate targets or signaling molecules of sarcotride A-induced increase of membrane potential. Further investigation is necessary to elucidate action mechanism of sarcotride A.
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KEYWORD
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Sarcotride A, Membrane potential, glioma
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