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KMID : 0606920060140020114
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Biomolecules & Therapeutics
2006 Volume.14 No. 2 p.114 ~ p.118
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Keum-Ryung-Ja-San, an Traditional Herbal Prescription, Ameliorates Depressive Behaviors in Mice
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Jung Ji-Wook
Lee Seung-joo
Yoon Byung-Hoon
Kim Dong-Hyun
Ryu Jong-Hoon
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Abstract
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Depression is a very difficult disease to be cured because several nervous systems are involved. In the present study, we evaluated the effect of Keum-Ryung-Ja-San (KRJS), a traditional herbal prescription, on depressive behaviors in mice using the forced swimming test. KRJS was given 1 h prior to the forced swimming test (50,100,200,and,400 mg/kg, p.o), The duration of immobility time in the forced swimming test was significantly reduced by KRJS treatment (200 mg/kg, p＜0.05) and similar effects were observed with a classical antidepressant, imipramine (15 mg/kg, i.p). With subchronic administrations of KRJS and its constituents at sev- eral doses for 1 week, a decreased duration of immobility time was observed with KRJS and Corydalis ternata(200 mg/kg, p.o. p＜0.05). These results suggest that KRJS may have antidepressive activities and CT may con- tribute to the antidepressive activity of KRJS.
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KEYWORD
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Keum-Ryung-Ja-San, antidepressant, Corydalis temata, Melia toosendan, forced swimming test
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