We reviewed thirteen patients with intracranial hemorrhage secondary to vitamine K deficiency, who were admitted to the Department of Neurosurgery, College of Medicine, Inha University from March 1990 to February 1994.
@ES The results were as follows:
@EN 1) The most common age of onset was under 2 months(12 cases, 92.3%). Sex ratio between male and female was 3.3 : 1(10:3).
2) In feeding history, breast feeding(7 cases, 53.8%) was most common, and followed by mixed feeding(4 case, 30.8%) and formular feeding(2 cases, 15.4%). Breast feeding, with or without formula, was 11 cases(84.6%) and intracranial hemorrhage
was
developed in breast feeding babies more than in formular feeding ones.
3) Clinical findings were variable: mental change(11 cases, 84%) was most common feature, and followed by irritability, poor sucking, vomiting, motor weakness, poor crying in order.
4) Subdural hemorrhage(9 cases, 69.2%) was most common and followed by intracerebral hemorrhage(7 cases, 53.9%) and intraventricular hemorrhage(3 cases, 23.1%), with or without other hemorrhage.
5) Prolongation of PT and vitamine K dependent coagulation factor deficiency were noted in all cases. APTT was prolongd in 11 cases(84.6%), but it was come back to normal range in all cases after vitamine K administration. Vitamine K1 level
checked in
5 cases was lower than normal.
6) Treatment included vitamine K administration, subdural tap, burr hole drainage, EVD or craniotomy. Short term result was not good(grade III+V ; 8 cases (61.8%)), but long term outcome would be worse than short term outcome(normal ; 1 case).
We though that intracranial hemorrhage in infants secondary to vitamine K deficiency may be developed in our country more than in western country because breast feeding is more frequently in our country. We though that vitamine K administration
is
better than none in pregnant women and infants.
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