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KMID : 0613820210310030298
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Journal of Life Science
2021 Volume.31 No. 3 p.298 ~ p.304
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Anti-aging and Anti-inflammatory Activities of the Extracts of Calamagrostis arundinacea
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Jeong Hea-Seok
Lee Dong-Ho
Lee Min-Sung
Heo Tae-Im
Kim Dong-Kap
Oh Seung-Hwan
Kim Du-Hyeon
Kim Yeong-Su
Kim Dae-Wook
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Abstract
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The anti-aging and anti-inflammatory activities of hot-water (Ca-HW) and 70% ethanol (Ca-E70) whole- plant Calamagrostis arundinacea extracts, as well as their bioactive potentials, were investigated using cell-free and cell-mediated experimental systems. Use of the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical decolorization assay to evaluate the antioxidant activity of the Ca-HW and Ca-E70 extracts revealed DPPH radical scavenging activities of 27% and 48%, respectively. Neither extract caused significant cytotoxicity, and both showed cell proliferation and promotion effects using RAW 264.7, B16F10, and CCD986sk cells. B16F10 melanoma cells showed higher melanin synthesis when treated with 100 mg/ml Ca-HW or Ca-E70 than with arbutin, indicating a stronger inhibitory effect of arbutin on melanin synthesis. Ca-HW and Ca-E70 increased pro-collagen biosynthesis in the human fibroblast CCD986-SK cell line by 24.69% and 12.55%, respectively. Analysis of the anti-inflammatory effects of different concentrations of Ca-HW and Ca-E70 in RAW264.7 cells revealed that Ca-E70 appeared to inhibit the lipopolysaccharide-induced production of nitric oxide and IL-6, a proinflammatory cytokine; therefore, Ca-E70 showed an anti-inflammatory effect. These results suggested that C. arundinacea extracts could have skin anti-aging and anti-inflammatory properties.
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KEYWORD
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Anti-inflammatory, Calamagrostis arundinacea, DPPH, melanin, pro-collagen
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