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KMID : 0620719980040030180
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Natural Product Sciences
1998 Volume.4 No. 3 p.180 ~ p.183
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Bioassay - guided Isolation of Deoxypodophyllotoxin , the Cytotoxic Constituent of Juniperus chinensis
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Ali, A. M.
Intan-Safinar, I
Mackeen, M. M.
El-Sharkawy, S. H.
Takahata, K.
Kanzaki, H.
Kawazu, K.
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Abstract
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The ethanol extract from the leaves of Juniperus chinensis was found to be cytcrtoxic towards HeLa cells. Bioassay-guided fractionation of the EtOAc soluble faction directed by the microtitration cytotoxic assay revealed that the cytotoxic comported was deoxypodophyllotoxin. All the tumour cell lines tested (KU8112F-chronic mylogeneous leukemia, TK 10-renal carcinoma, UACC 62-melanoma and (CEM-SS-T-lymphoblastic leukemia) were found to be susceptible to deoxypodaphyllotoxin, however, floe minimum effective concentration (MEC) required to reduce the cell population by 100 percent was different between cell lines.
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