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KMID : 0620719980040040241
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Natural Product Sciences
1998 Volume.4 No. 4 p.241 ~ p.244
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Inhibitory Activities of Korean Plants on HIV-1 Protease
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Kim, Young Ho
Min, Byung Sun/Bae, Ki Hwan/Kunitada Shimotono/Hirotsugu Miyashiro/Masao Hattori
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Abstract
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For the development of anti-AIDS agents, thirty-seven methanol extracts of Korean plant materials were tested for their inhibitory effects on human immunodeficiency virus type-1 (HIV-1) protease. Extracts of seven plants showed more than 30% inhibitory activities on HIV-1 protease at a concentration of 100 ㎍/㎖. The bark of Berekemia berchemiaefolia, the leaf of Lindera erythrocarpa and the whole plant of Siegesbsekia pubescens exhibited significant inhibititory activities on HIV-1 protease with 56.2, 50.8, and 46.6%, respectively.
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