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KMID : 0620720030090020093
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Natural Product Sciences
2003 Volume.9 No. 2 p.93 ~ p.96
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In vitro Antiinflammatory Activity of the Essential oil Extracted from Chrysanthemum sibiricum in Murine Macrophage RAW 264.7 Cells
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Lee, Kyung-Tae
Kim, Ryung-Kyu/Ji, Sa-Young/Shin, Kyoung-Min/Choi, Jong-Won/Jung, Hyun-Ju/Park, Hee-Juhn
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Abstract
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This research was undertaken to find the in vitro inflammatory action of the essential oil (CS-oil) extracted from Chrysanthemun sibiricum (Compositae) herbs. We investigated the effects of the CS-oil not only on the formation NO, PGE_2, and TNF-α but also on inducible nitric oxide synthase and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced murine macrophage RAW 26.47 cells. The data obtained were consistent with the modulation of iNOS enzyme expression. A similar fashion was also observed when LPS-induced, PGE_2 release and COX-2 expression were tested. The significant inhibitory effects were shown in concentration-dependent manners. In addition, CS-oil also mildly but significantly reduced the formation of TNF-a. These findings support the application of CS-oil as an antiinflammatory essential oil.
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