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KMID : 0620720030090020097
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Natural Product Sciences
2003 Volume.9 No. 2 p.97 ~ p.101
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Sulfuretin, an Antinociceptive and Antiinflammatory Flavonoid from Rhus verniciflua
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Choi, JongWon
Yoon, Byung-Jae/Han, Yong Nam/Lee, Sang Kook/Lee, Kyung-Tae/Park, Hee-Juhn
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Abstract
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This study was undertaken to evaluate the antinociceptive and antiinflammatory effects of the heartwood extract of Rhus verniciflua (Anacardiaceae) and the two major components, sulfuretin and fustin. The MeoH extract, its EtOAc-soluble portion and sulfuretin showed significant antinociceptive activity in writhing and hot plate test assays and antinnflammory effects in carraggenan-induce hind paw edema in rats. In particular, treatment of sulfuretin with 10㎎/㎏ dose (i.p.) reduced writhing frequency by 48.0% (p＜0.01) compared to that of a control group. Further, the treatment of sulfuretin (5, 10㎎/㎏, i.p.) for 7 days prevented the carrageenan-induced hind paw edema significantly (p＜0.01). The antinnflammatory effect of sulfuretin was also confirmed by microscopic observation of mast cell numbers in muscle. In addition, sulfuretin suppressed the cyclooxygenase-2 (COX-2) activity (IC_50 = 28.7??M) in lipopolysaccharide-activated macrophage cells. This result indicates that the inhibitory effect of sulfuretin on COX-2 may be one of the antinociceptive/antinnflammatory mechanism.
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