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KMID : 0620720030090040273
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Natural Product Sciences
2003 Volume.9 No. 4 p.273 ~ p.277
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Immunomodulatory activity of Salicornia herbacea L. Components
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Im, Sun-A
Kim, Goo-Whan/Lee, Chong-Kil
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Abstract
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Suliconiiu herbacea is an annual herb growing in salt marshes and on muddy seashores. Sulicomia herbaceu has been used as a fork medicine as well as a seaoned vegetable. In fork medicine, Sulicomia herbucea has been used to treat a variety of diseases such as constipation, obesity, diabetes, asthma, arthritis and cancer. However, the biological mechanisms for these activities have not been characterized, nor the active components. The immunomodulatory activity of Salicorniu herbaceu components were studied in the present study. The components of Salicomiu herbacen were prepared from the whole plant by passage through a fine screen, and then dialyzed against PBS overnight. Immunomodulatory activities of the Sulicomiu herbucea components were examined on a mouse macrophage cell line, RAW 264.7 cells. The Salicomiu herbacea components were shown to stimulate cytokine production, nitric oxide release, and expression of surface molecules in a dose dependent manner. The Sulicorniu herbacen components also induced further differentiation of slightly adherent RAW 264.7 cell into strongly adherent macrophages These results indicate that Sulicomiu herbucea contains immunomodulatofls) that induces activation of macrophages.
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