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KMID : 0620720180240040259
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Natural Product Sciences
2018 Volume.24 No. 4 p.259 ~ p.265
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Isolation of Flavonoid Glycosides with Cholinesterase Inhibition Activity and Quantification from Stachys japonica
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Nugroho Agung
Choi Jae-Sue
Seong Su-Hui
Song Byong-Min
Park Kyoung-Sik
Park Hee-Juhn
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Abstract
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The three flavone glycosides, 4'-O-methylisoscutellarein 7-O-(6'''-O-acetyl)-b-D-allopyranosyl(1→2)-b-D-glucopyranoside (1), isoscutellarein 7-O-(6'''-O-acetyl)-b-D-allopyranosyl(1→2)-b-D-glucopyranoside (3), and isoscutellarein 7-O-b-D-allopyranosyl(1→2)-b-D-glucopyranoside (4) in addition to a flavonol glycoside, kaempferol 3-O-b-D-glucopyranoside (astragalin, 2), were isolated from Stachys japonica (Lamiaceae). In cholinesterase inhibition assay, compound 1 significantly inhibited aceylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities (IC50s, 39.94 mg/ml for AChE and 86.98 mg/ml for BChE). The content of isolated compounds were evaluated in this plant extract by HPLC analysis. Our experimental results suggest that the flavonoid glycosides of S. japonica could prevent the memory impairment of Alzheimer's disease.
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KEYWORD
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Stachys japonica, Lamiaceae, isoscutellarein glycoside, cholinesterase, Alzheimer’s disease
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