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KMID : 0620720180240040284
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Natural Product Sciences
2018 Volume.24 No. 4 p.284 ~ p.287
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Acronyculatin P, A New Isoprenylated Acetophenone from the Stem Bark of Acronychia pedunculata
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Tanjung Mulyadi
Nurmalasari Intan
Wilujeng Aisyah Kanti
Saputri Ratih Dewi
Rachmadiarti Fida
Tjahjandarie Tjitjik Srie
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Abstract
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A new isoprenylated acetophenone, acronyculatin P (1) as well as two known compounds, 3',5'-diisoprenyl-2',4'-dihydroxy-6'-methoxyphenylethanone (2) and 3'-isoprenyl-2',4',6'-trihydroxyphenylethanone (3) were isolated from the stem bark of Acronychia pedunculata (L.) Miq. The structures were determined by HRESIMS, 1D and 2D NMR. The inhibitory activity of the isoprenylated acetophenone derivatives against murine leukemia P-388 cells showed compound 1 moderate activity with IC50 15.42 mM.
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KEYWORD
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Acronyculatin P, isoprenylated acetophenone, Acronychia pedunculata, P-388 cells
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